Abstract The development of multitarget small molecules (MSMs) has emerged as a powerful strategy for the treatment of multifactorial diseases such as cancer.Glioblastoma is the most prevalent and malignant primary brain tumor in adults, which is characterized by poor prognosis and a high heterogeneity.Current standards of treatment present limited
Case summary Two 18-day-old domestic shorthair kittens presented with dyspnoea, mild cyanosis, heart murmur, lung pattern, abnormal crawling and a marked dorsoventral flattening of the thorax.Deformity of the thoracic wall without pectus excavatum was diagnosed.Cardboard corsets tailored to each kitten were applied.This gave immediate respiratory r
Musicians are trained in melodic transposition, the skill of extracting the pitch interval structure and moving it into different keys.This ability to recognize whether a melody is the same or altered when it is played back in a different key is correlated with both greater neural activation and cortical thickness in bilateral intraparietal sulcus
Establishing an association between possible food sources and clinical isolates requires discriminating the suspected pathogen from an environmental background, and distinguishing it from other closely-related foodborne pathogens.We used whole genome sequencing (WGS) to Salmonella subspecies enterica serotype Tennessee (S.Tennessee) to describe gen